Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage.

@article{Ohneda2002RolesOH,
  title={Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage.},
  author={Kinuko Ohneda and Masayuki Yamamoto},
  journal={Acta haematologica},
  year={2002},
  volume={108 4},
  pages={237-45}
}
The transcription factors GATA-1 and GATA-2 play key roles in gene regulation during erythropoiesis. Gene ablation studies in mouse revealed that GATA-2 is crucial for the maintenance and proliferation of immature hematopoietic progenitors, whereas GATA-1 is essential for the survival of erythroid progenitors as well as the terminal differentiation of erythroid cells. Both GATA-1 and GATA-2 are regulated in a cell-type-specific manner, their expression being strictly controlled during the… CONTINUE READING