Roles of focal adhesions and fibronectin-mediated cohesion in proliferation of confluent fibroblasts.

@article{Tanaka2009RolesOF,
  title={Roles of focal adhesions and fibronectin-mediated cohesion in proliferation of confluent fibroblasts.},
  author={Maya Tanaka and Tatsuya Abe and Yoshitaka Hara},
  journal={Journal of cellular physiology},
  year={2009},
  volume={219 1},
  pages={
          194-201
        }
}
Multilayered fibroblast sheets have applications as cell transplants for tissue engineering. One way to increase their therapeutic efficacy is to increase cell numbers in a graft, but the factors influencing multilayered growth remain poorly understood. In this study, we investigated the roles of focal adhesion (FA) assembly and intercellular cohesion through fibronectin (FN) in the proliferation of normal human fibroblasts at confluence. Density-dependent growth-arrested fibroblasts resumed… CONTINUE READING
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