Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

@article{Pommier2016RolesOE,
  title={Roles of eukaryotic topoisomerases in transcription, replication and genomic stability},
  author={Yves Pommier and Yilun Sun and Shar-yin N. Huang and John L Nitiss},
  journal={Nature Reviews Molecular Cell Biology},
  year={2016},
  volume={17},
  pages={703-721}
}
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove catenanes and enable chromosome segregation. Human cells encode six topoisomerases (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α and TOP3β), which act on a broad range of DNA and RNA substrates at the nuclear and mitochondrial genomes. Their catalytic intermediates, the topoisomerase cleavage complexes (TOPcc), are therapeutic targets of various anticancer drugs. TOPcc can also form on damaged DNA during replication and… CONTINUE READING
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