Roles of estrogen receptor alpha (ER alpha) in the regulation of the human Müllerian inhibitory substance (MIS) promoter.

@article{Chen2003RolesOE,
  title={Roles of estrogen receptor alpha (ER alpha) in the regulation of the human M{\"u}llerian inhibitory substance (MIS) promoter.},
  author={Gang Chen and Toshikatsu Shinka and Keigo Kinoshita and Hong-tao Yan and Teruaki Iwamoto and Yutaka Nakahori},
  journal={The journal of medical investigation : JMI},
  year={2003},
  volume={50 3-4},
  pages={192-8}
}
Sex differentiation consists of multi-step pathway that involves expression of many different genes. Müllerian duct inhibitory substance (MIS) has a key role for regression of the Müllerian duct during male sex differentiation. Recently, endocrine disruptors (EDs), which often have estrogen-like activities, have caused concern over worldwide. It has been reported that estrogen regulates the MIS expression. Therefore, we tested whether ER alpha and ER beta influence the MIS promoter activity in… CONTINUE READING