Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.

@article{Sidhu2010RolesOE,
  title={Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.},
  author={Sukhvinder S. Sidhu and Shaopeng Yuan and Anh L Innes and Sheena C. Kerr and Prescott G. Woodruff and Lydia Hou and Susan J. Muller and John V Fahy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 32},
  pages={14170-5}
}
Periostin is considered to be a matricellular protein with expression typically confined to cells of mesenchymal origin. Here, by using in situ hybridization, we show that periostin is specifically up-regulated in bronchial epithelial cells of asthmatic subjects, and in vitro, we show that periostin protein is basally secreted by airway epithelial cells in response to IL-13 to influence epithelial cell function, epithelial-mesenchymal interactions, and extracellular matrix organization. In… CONTINUE READING