Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons.

@article{Surh1994RolesOE,
  title={Roles of electrophilic sulfuric acid ester metabolites in mutagenesis and carcinogenesis by some polynuclear aromatic hydrocarbons.},
  author={Y. Surh and J. Miller},
  journal={Chemico-biological interactions},
  year={1994},
  volume={92 1-3},
  pages={
          351-62
        }
}
  • Y. Surh, J. Miller
  • Published 1994
  • Chemistry, Medicine
  • Chemico-biological interactions
Hydroxylation of meso-methyl groups with subsequent formation of reactive benzylic esters bearing a good leaving group (e.g. sulfate) was proposed as a possible biochemical mechanism of activation and tumorigenicity of methyl-substituted polycyclic aromatic hydrocarbons (PAHs). In support of this postulation, recent studies have demonstrated the formation by rodent hepatic sulfotransferase activity of electrophilic, mutagenic, and carcinogenic sulfuric acid esters of several hydroxymethyl… Expand
Sulfotransferase-mediated activation of some benzylic and allylic alcohols.
  • Y. Surh
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 1996
9-Sulfooxymethylanthracene is an ultimate electrophilic and carcinogenic form of 9-hydroxymethylanthracene.
Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents.
7-Sulfooxymethyl-12-methylbenz[a]anthracene is an exceptionally reactive electrophilic mutagen and ultimate carcinogen.
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