Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains

@article{Pelletier1995RolesOD,
  title={Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains},
  author={C. Pelletier and Patrice Prognon and Pierre Bourlioux},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1995},
  volume={39},
  pages={707 - 713}
}
The antibacterial activity of nitroxoline (NIT), an antibiotic used in the treatment of acute or recurrent urinary tract infections caused by Escherichia coli, is decreased in the presence of Mg2+ and Mn2+ but not Ca2+. In order to elucidate the interaction between this drug and the divalent cations, spectrophotometric studies based on the natural absorption of the nitroxoline moiety were conducted. In the presence of the divalent metal ions, a shift in the NIT A448 suggested the formation of… Expand
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