Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.

  title={Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.},
  author={Genta Ito and Hiroyoshi Ariga and Yasuhito Nakagawa and Takeshi Iwatsubo},
  journal={Biochemical and biophysical research communications},
  volume={339 2},
A significant proportion of early onset parkinsonism is inherited as an autosomal-recessive trait (AR-EP). DJ-1 was identified as one of the causative genes for AR-EP (PARK7), and DJ-1 protein has been implicated in oxidative stress response through oxidation of one of the three cysteine residues (i.e., Cys106). However, the individual roles of these cysteine residues remained unclear. We show by a systematic mutagenesis analysis that Cys46 and Cys53 of DJ-1, but not Cys106, are susceptible to… CONTINUE READING
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