Roles of cyclic diguanylate in the regulation of bacterial pathogenesis.

  title={Roles of cyclic diguanylate in the regulation of bacterial pathogenesis.},
  author={Rita Tamayo and Jason T Pratt and Andrew Camilli},
  journal={Annual review of microbiology},
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways… CONTINUE READING

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