Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations.

@article{Jin2007RolesOC,
  title={Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations.},
  author={Denan Jin and Haruhiko Ueda and Shinji Takai and Michiko Muramatsu and Keiichi Furubayashi and Toshihiko Ibaraki and Kanta Kishi and Yoji Katsuoka and Mizuo Miyazaki},
  journal={Life sciences},
  year={2007},
  volume={81 16},
  pages={1291-300}
}
Chymase is an important enzyme for the generation of angiotensin (Ang) II and in the activation of transforming growth factor (TGF)-beta1. Therefore, chymase may be involved in the hemodialysis access dysfunction, which is caused by intimal hyperplasia that occurs after polytetrafluoroethylene (PTFE) graft implantations. Bilateral U-shaped PTFE grafts were placed between the femoral vein and artery in dogs. Chymase inhibitor (NK3201, 1 mg/kg per day, p.o.) treatments were initiated 3 days… CONTINUE READING