Roles of chromatin remodeling factors in the formation and maintenance of heterochromatin structure.

@article{Yu2011RolesOC,
  title={Roles of chromatin remodeling factors in the formation and maintenance of heterochromatin structure.},
  author={Qun Yu and Xinmin Zhang and Xin Bi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 16},
  pages={14659-69}
}
Heterochromatin consists of highly ordered nucleosomes with characteristic histone modifications. There is evidence implicating chromatin remodeling proteins in heterochromatin formation, but their exact roles are not clear. We demonstrate in Saccharomyces cerevisiae that the Fun30p and Isw1p chromatin remodeling factors are similarly required for transcriptional silencing at the HML locus, but they differentially contribute to the structure and stability of HML heterochromatin. In the absence… CONTINUE READING