Roles of caspase-1 in Listeria infection in mice.

  title={Roles of caspase-1 in Listeria infection in mice.},
  author={Noriko M. Tsuji and Hiroko Tsutsui and Ekihiro Seki and Keisuke Kuida and Haruki Okamura and Kenji Nakanishi and Richard A Flavell},
  journal={International immunology},
  volume={16 2},
Caspase-1 [IL-1beta-converting enzyme (ICE)] processes substrate precursor molecules to yield the biologically active form of IL-1beta and IL-18, both of which are considered to play important roles in the host defense by activation of both innate and adaptive immunity. We evaluated the immune response of caspase-1(-/-) mice to Listeria monocytogenes (LM) infection. LM eradication in the early phase of infection was impaired in the mutant mice with a prominent decrease in IL-18 and IFN-gamma… CONTINUE READING


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