Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.

@article{Phrommintikul2006RolesOC,
  title={Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.},
  author={Arintaya Phrommintikul and Nipon Chattipakorn},
  journal={International journal of cardiology},
  year={2006},
  volume={112 2},
  pages={142-52}
}
Calcium (Ca2+) plays an important role as a messenger in the excitation-contraction coupling process of the myocardium. It is stored in the sarcoplasmic reticulum (SR) and released via a calcium release channel called the ryanodine receptor. Cardiac ryanodine receptor (RyR2) controls Ca2+ release, which is essential for cardiac contractility. There are several molecules which bind and regulate the function of RyR2 including calstabin2, calmodulin, protein kinase A (PKA), phosphatase, sorcin and… CONTINUE READING