Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity.

@article{Nelson2013RolesOC,
  title={Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity.},
  author={William James Nelson and Daniel J. Dickinson and William I Weis},
  journal={Progress in molecular biology and translational science},
  year={2013},
  volume={116},
  pages={3-23}
}
A simple epithelium is the building block of all metazoans and a multicellular stage of a nonmetazoan. It comprises a closed monolayer of quiescent cells that surround a luminal space. Cells are held together by cell-cell adhesion complexes and surrounded by extracellular matrix. These extracellular contacts are required for the formation of a polarized organization of plasma membrane proteins that regulate the directional absorption and secretion of ions, proteins, and other solutes. While… CONTINUE READING