Roles of brain angiotensins II and III in thirst and sodium appetite.

  title={Roles of brain angiotensins II and III in thirst and sodium appetite.},
  author={Wendy Lee Wilson and B. Roques and C Llorens-cortes and Robert C Speth and Joseph W. Harding and John W. Wright},
  journal={Brain research},
  volume={1060 1-2},
The current study examined the effects of intracerebroventricular (icv) infused aminopeptidase-resistant analogs of angiotensin II (AngII) and angiotensin III (AngIII) on thirst and sodium appetite. The analogs, [D-Asp1D-Arg2]AngII and [D-Arg1]AngIII, were further protected from degradation by pretreatment with the aminopeptidase A inhibitor, EC33, or the aminopeptidase N inhibitor, PC18. Prior to icv infusions, rats were sodium depleted with furosemide, followed by the angiotensin-converting… CONTINUE READING


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