Roles of brain angiotensin II and C-type natriuretic peptide in deoxycorticosterone acetate-salt hypertension in rats.

@article{Nishimura1998RolesOB,
  title={Roles of brain angiotensin II and C-type natriuretic peptide in deoxycorticosterone acetate-salt hypertension in rats.},
  author={Masaharu Nishimura and Ken Ohtsuka and Masakatsu Sakamoto and Akira Nanbu and Hakuo Takahashi and Manabu Yoshimura},
  journal={Journal of hypertension},
  year={1998},
  volume={16 8},
  pages={
          1175-85
        }
}
OBJECTIVE To investigate the roles of brain angiotensin II and C-type natriuretic peptide (CNP) in the hypertensive mechanism of deoxycorticosterone acetate (DOCA)-salt hypertension. METHODS We injected 50 microg/kg CV-11 974, an angiotensin II type-1 receptors antagonist, 30 nmol/kg CNP-22, or the vehicle (artificial cerebrospinal fluid) into the cerebral ventricle or intravenously 5 min before the intracerebroventricular infusion of 1.5 mol/I NaCl solution for 30 min into either male… CONTINUE READING

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