Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

@article{Fujii1999RolesOB,
  title={Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.},
  author={Makiko Fujii and Kiyoshi Takeda and Takeshi Imamura and Hitomi Aoki and T. Kuber Sampath and Shoji Enomoto and Masahiro Kawabata and Mitsuyasu Kato and Hidenori Ichijo and Kohei Miyazono},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 11},
  pages={
          3801-13
        }
}
The biological effects of type I serine/threonine kinase receptors and Smad proteins were examined using an adenovirus-based vector system. Constitutively active forms of bone morphogenetic protein (BMP) type I receptors (BMPR-IA and BMPR-IB; BMPR-I group) and those of activin receptor-like kinase (ALK)-1 and ALK-2 (ALK-1 group) induced alkaline phosphatase activity in C2C12 cells. Receptor-regulated Smads (R-Smads) that act in the BMP pathways, such as Smad1 and Smad5, also induced the… CONTINUE READING
132 Citations
62 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 132 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Similar Papers

Loading similar papers…