Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.

@article{MartnezMartnez1999RolesOB,
  title={Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.},
  author={Luis Horacio Mart{\'i}nez-Mart{\'i}nez and {\'A}lvaro Pascual and Santiago Hern{\'a}ndez-All{\'e}s and D Alvarez-D{\'i}az and Ana Isabel Su{\'a}rez and J. J. Tran and Vicente Javier Bened{\'i} and George A. Jacoby},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 7},
  pages={1669-73}
}
Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of beta-lactamase in resistance was investigated by eliminating the original ESBL and introducing plasmids encoding various ESBLs and AmpC beta-lactamase types, by studying the effect of an increased inoculum, and by evaluating interactions with… CONTINUE READING