Roles of basophils and mast cells in cutaneous inflammation

  title={Roles of basophils and mast cells in cutaneous inflammation},
  author={Atsushi Otsuka and Yumi Nonomura and Kenji Kabashima},
  journal={Seminars in Immunopathology},
Mast cells and basophils are associated with T helper 2 (Th2) immune responses. Newly developed mast cell-deficient mice have provided evidence that mast cells initiate contact hypersensitivity via activating dendritic cells. Studies using basophil-deficient mice have also revealed that basophils are responsible for cutaneous Th2 skewing to haptens and peptide antigens but not to protein antigens. Recently, several studies reported the existence of innate lymphoid cells (ILCs), which differ… CONTINUE READING
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Innate production of T(H)2 cytokines by adipose tissueassociated c-Kit(+)Sca-1(+) lymphoid cells

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