Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury.

@article{Wu2001RolesOA,
  title={Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury.},
  author={Lan Wu and Masaru Iwai and Hironori Nakagami and Zhen Li and Rui Chen and Jun Suzuki and Masahiro Akishita and Marc de Gasparo and Masatsugu Horiuchi},
  journal={Circulation},
  year={2001},
  volume={104 22},
  pages={2716-21}
}
BACKGROUND To investigate the effect of angiotensin (Ang) II type 1 receptor (AT(1)) blocker on vascular remodeling and explore the possibility of the involvement of Ang II type 2 receptor (AT(2)) stimulation in this process, we examined the effects of the selective AT(1) blocker valsartan on the vascular injury in wild-type (Agtr2+) and AT(2)-null (Agtr2-) mice. METHODS AND RESULTS Neointima formation and the proliferation of vascular smooth muscle cells (VSMCs) induced by cuff placement on… CONTINUE READING
84 Extracted Citations
27 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 84 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 27 references

IKK-1 and IKK-2: cytokine-activated I B kinases essential for NF- B activation

  • F Mercurio, H Zhu, BW Murray
  • 2001

Similar Papers

Loading similar papers…