Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

  title={Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory},
  author={P. R. Turner and K. O'Connor and W. Tate and W. Abraham},
  journal={Progress in Neurobiology},
  • P. R. Turner, K. O'Connor, +1 author W. Abraham
  • Published 2003
  • Psychology, Medicine
  • Progress in Neurobiology
  • Amyloid-beta precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain. It is the source of the amyloid-beta (Abeta) peptide found in neuritic plaques of Alzheimer's disease (AD) patients. Because Abeta shows neurotoxic properties, and because familial forms of AD promote Abeta accumulation, a massive international research effort has been aimed at understanding the mechanisms of Abeta generation, catabolism and toxicity… CONTINUE READING
    678 Citations
    Physiological role of amyloid precursor protein during neural development
    • PDF
    Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease
    • 43
    Amyloid precursor protein (APP) regulates synaptic structure and function
    • 133
    The amyloid precursor protein and postnatal neurogenesis/neuroregeneration.
    • Ya'nan Chen, B. Tang
    • Biology, Medicine
    • Biochemical and biophysical research communications
    • 2006
    • 39
    Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity
    • 37
    • PDF
    Amyloid precursor protein: cellular studies and animal models
    • 1
    • Highly Influenced
    The human β-amyloid precursor protein: biomolecular and epigenetic aspects
    • K. Nguyen
    • Biology, Medicine
    • Biomolecular concepts
    • 2015
    • 17
    • PDF
    Investigation of secreted amyloid precursor protein-α binding partners


    Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices
    • 116
    • PDF
    Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.
    • 270
    • PDF
    Nicotine and its interaction with β-amyloid protein: a short review
    • 37
    Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.
    • 932
    • PDF