Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

  title={Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory},
  author={P. R. Turner and K. O'Connor and W. Tate and W. Abraham},
  journal={Progress in Neurobiology},
  • P. R. Turner, K. O'Connor, +1 author W. Abraham
  • Published 2003
  • Medicine, Biology
  • Progress in Neurobiology
  • Amyloid-beta precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain. It is the source of the amyloid-beta (Abeta) peptide found in neuritic plaques of Alzheimer's disease (AD) patients. Because Abeta shows neurotoxic properties, and because familial forms of AD promote Abeta accumulation, a massive international research effort has been aimed at understanding the mechanisms of Abeta generation, catabolism and toxicity… CONTINUE READING
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