Roles of adenosine A(1) and A(2A) receptors in the expression and development of methamphetamine-induced sensitization.

@article{Shimazoe2000RolesOA,
  title={Roles of adenosine A(1) and A(2A) receptors in the expression and development of methamphetamine-induced sensitization.},
  author={Takao Shimazoe and Akiko Yoshimatsu and A Kawashimo and Shigenori Watanabe},
  journal={European journal of pharmacology},
  year={2000},
  volume={388 3},
  pages={249-54}
}
We studied the effects of adenosine A(1) and A(2A) receptor agonists on the expression and development of methamphetamine-induced sensitization in rats. When animals were treated with the adenosine A(1) receptor agonist, N(6)-cyclohexyladenosine (CHA), along with methamphetamine every 3 days with a total of five administrations, the augmentation of hyperlocomotion by methamphetamine re-administration after 7-day withdrawal (methamphetamine challenge administration) was not inhibited. However… CONTINUE READING

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