Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride).

@article{Hmlinen1998RolesOA,
  title={Roles of acid/base nature and molecular weight in drug release from matrices of gelfoam and monoisopropyl ester of poly(vinyl methyl ether-maleic anhydride).},
  author={Kirsi M. H{\"a}m{\"a}l{\"a}inen and E M{\"a}{\"a}tt{\"a} and Helena Piirainen and Marianne Sarkola and Ari O V{\"a}is{\"a}nen and V P Ranta and Arto Urtti},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1998},
  volume={56 1-3},
  pages={273-83}
}
Ophthalmic drug inserts are usually placed in the conjunctival sac. Being in contact with the conjunctiva, they may provide means to deliver large and hydrophilic molecules, such as peptides and oligonucleotides into the eye. We evaluated Gelfoam and monoisopropyl ester of poly(vinyl methyl ether/maleic anhydride) (PVM/MA) as potential polymers for ocular inserts. Matrices were solvent cast with model drugs that had different pKa, molecular weight and hydrophilicity. Drug release from the… CONTINUE READING