Roles of Volume-sensitive Cl− Channel in Cisplatin-induced Apoptosis in Human Epidermoid Cancer Cells

@article{Ise2005RolesOV,
  title={Roles of Volume-sensitive Cl− Channel in Cisplatin-induced Apoptosis in Human Epidermoid Cancer Cells},
  author={Tomoko Ise and Takahiro Shimizu and Elbert Lan Lee and Hiroki Inoue and Kenji Kohno and Yasunobu Okada},
  journal={The Journal of Membrane Biology},
  year={2005},
  volume={205},
  pages={139-145}
}
The anti-cancer drug cisplatin induces apoptosis by damaging DNA. Since a stilbene-derivative blocker of Cl−/HCO 3 − exchangers and Cl− channels, SITS, is known to induce cisplatin resistance in a manner independent of intracellular pH and extracellular HCO 3 − , we investigated the relation between cisplatin-induced apoptosis and Cl− channel activity in human adenocarcinoma KB cells. A stilbene derivative, DIDS, reduced cisplatin-induced caspase-3 activation and cell death, which were detected… CONTINUE READING
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