Roles of TGFβ signaling Smads in squamous cell carcinoma

@inproceedings{Han2011RolesOT,
  title={Roles of TGFβ signaling Smads in squamous cell carcinoma},
  author={Gangwen Han and Xiao-Jing Wang},
  booktitle={Cell & Bioscience},
  year={2011}
}
Smad proteins are classified in different groups based on their functions in mediating transforming growth factor β (TGFβ) superfamily components. Smad1/5/8 mainly mediate bone morphogenetic proteins (BMP) pathway and Smad2/3 mainly mediate TGFβ pathway. Smad4 functions as common Smad to mediate both pathways. Previous studies showed many members of TGFβ superfamily play a role in carcinogenesis. The current review focuses on the role of TGFβ signaling Smads in squamous cell carcinomas (SCCs… CONTINUE READING
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