Roles of Sox factors in neural determination: conserved signaling in evolution?

@article{Sasai2001RolesOS,
  title={Roles of Sox factors in neural determination: conserved signaling in evolution?},
  author={Yoshiki Sasai},
  journal={The International journal of developmental biology},
  year={2001},
  volume={45 1},
  pages={321-6}
}
  • Yoshiki Sasai
  • Published 2001 in
    The International journal of developmental…
Neural differentiation in amphibian embryos is initiated by the neural inducers emanating from the Spemann-Mangold organizer. The fate of uncommitted ectoderm is determined by graded BMP activity along the dorsal-ventral axis. Several transcriptional regulators acting in early neural differentiation have been identified, including Sox, Zic, Pou, HLH and Fox factors. In this paper, I review recent molecular studies on neural determination, focusing mainly on Sox factors. I also discuss the… CONTINUE READING