Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis.

@article{Okuno2010RolesOS,
  title={Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis.},
  author={Tatsusada Okuno and Yuji Nakatsuji and Masayuki Moriya and Hyota Takamatsu and Satoshi Nojima and Noriko Takegahara and Toshihiko Toyofuku and Yukinobu Nakagawa and Sujin Kang and Roland H Friedel and Saburo Sakoda and Hitoshi Kikutani and Atsushi Kumanogoh},
  journal={Journal of immunology},
  year={2010},
  volume={184 3},
  pages={
          1499-506
        }
}
Although semaphorins were originally identified as axonal guidance molecules during neuronal development, it is emerging that several semaphorins play crucial roles in various phases of immune responses. Sema4D/CD100, a class IV semaphorin, has been shown to be involved in the nervous and immune systems through its receptors plexin-B1 and CD72, respectively. However, the involvement of Sema4D in neuroinflammation still remains unclear. We found that Sema4D promoted inducible NO synthase… CONTINUE READING
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