Roles of STAT3 defined by tissue-specific gene targeting

@article{Akira2000RolesOS,
  title={Roles of STAT3 defined by tissue-specific gene targeting},
  author={Shizuo Akira},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={2607-2611}
}
The physiological role of each individual STAT protein is now being examined through the study of ‘knockout’ (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis. However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3… CONTINUE READING
141 Citations
9 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 141 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Int

  • H Akaishi, K Takeda, +4 authors S. Akira
  • Immunol., 10, 1747 ± 1751.
  • 1998
Highly Influential
4 Excerpts

Immunity, 10, 39 ± 49

  • I FoÈ rster, S. Akira
  • Takeda K, Kaisho T, Yoshida N, Takeda J…
  • 1999

Cell, 93, 841 ± 850

  • Ihle JN.
  • Weber-Nordt RM, Riley JK, Greenlund AC, Moore KW,
  • 1998

Dev

  • SA Duncan, Z Zhong, Z Wen, JE. Darnell
  • Dyn., 208, 190 ± 198.
  • 1997
2 Excerpts

Immunity, 7, 691 ± 701

  • WJ.
  • Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba…
  • 1997

Proc

  • N Yoshida, T Kishimoto, S. Akira
  • Natl.
  • 1997

J

  • JE Darnell, Schreiber RD.
  • Biol. Chem., 271,
  • 1996

Mol

  • F. Horn
  • Cell. Biol., 13, 276 ± 288. Wen Z, Zhong Z and…
  • 1993

Similar Papers

Loading similar papers…