Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.

@article{Xiong2012RolesOS,
  title={Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.},
  author={H. W. Xiong and Jie Hong and Wan Tong Du and Yan-wei Lin and Lin-lin Ren and Ying-chao Wang and Wen-Yu Su and Ji-Lin Wang and Yun Cheng Cui and Zhenhua Wang and Jingyuan Fang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 8},
  pages={5819-32}
}
The progression of colorectal carcinoma (CRC) to invasive and metastatic disease may involve localized occurrences of epithelial-mesenchymal transition (EMT). However, mechanisms of the EMT process in CRC progression are not fully understood. We previously showed that knockdown of signal transducer and activator of transcription 3 (STAT3) up-regulated E-cadherin (a key component in EMT progression) in CRC. In this study, we examined the roles of STAT3 in CRC EMT and ZEB1, an EMT inducer, in… CONTINUE READING
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