• Corpus ID: 35473372

Roles of SIRT 1 and Phosphoinositide 3OH Kinase / Protein Kinase C Pathways in Evodiamine-Induced Human Melanoma A 375-S 2 Cell Death

  title={Roles of SIRT 1 and Phosphoinositide 3OH Kinase / Protein Kinase C Pathways in Evodiamine-Induced Human Melanoma A 375-S 2 Cell Death},
  author={Che Wang and Min-wei Wang and Shin-ichi Tashiro and Satoshi Onodera and Takashi Ikejima},
We previously demonstrated that evodimine isolated from Evodia rutaecarpa (Goshuyu in Japan) induced apoptosis in human malignant melanoma A375-S2 cells within 24 h. In this study, TUNEL assay also indicated that one cause of A375-S2 cell death induced by evodiamine was apoptosis. After treatment with evodiamine for the indicated time periods, antiapoptotic protein SIRT1 expression was decreased; p53 expression and its phosphorylation were both enhanced, whereas transient induction of… 
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