Roles of PSF protein and VL30 RNA in reversible gene regulation.

  title={Roles of PSF protein and VL30 RNA in reversible gene regulation.},
  author={X J Song and Ying Sun and Alan Garen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 34},
The mammalian protein PSF contains a DNA-binding domain (DBD) that coordinately represses multiple oncogenic genes in human cell lines, indicating a role for PSF as a human tumor-suppressor protein. PSF also contains two RNA-binding domains (RBD) that form a complex with a noncoding VL30 retroelement RNA, releasing PSF from a gene and reversing repression. Thus, the DBD and RBD in PSF are linked by a mechanism of reversible gene regulation involving a noncoding RNA. This mechanism also could… CONTINUE READING
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