Roles of P-selectin in inflammation, neointimal formation, and vascular remodeling in balloon-injured rat carotid arteries.

@article{Hayashi2000RolesOP,
  title={Roles of P-selectin in inflammation, neointimal formation, and vascular remodeling in balloon-injured rat carotid arteries.},
  author={Shigeoki Hayashi and Nozomi Watanabe and Kazuo Nakazawa and Jun Suzuki and Kenji Tsushima and Takuya Tamatani and Seisuke Sakamoto and Mitsuaki Isobe},
  journal={Circulation},
  year={2000},
  volume={102 14},
  pages={1710-7}
}
BACKGROUND P-selectin plays key roles in mediating inflammation through promoting adherence of leukocytes to activated platelets and endothelium. This process is one of the initial events in atherosclerosis and restenosis after coronary angioplasty. METHODS AND RESULTS Using a rat balloon-injury model, we examined the role of P-selectin in vascular inflammatory processes. In the acute phase, immunohistochemistry revealed that P-selectin was intensely expressed on both activated platelets… CONTINUE READING
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