Roles of NOD 1 ( NLRC 1 ) and NOD 2 ( NLRC 2 ) in innate immunity and inflammatory diseases

@inproceedings{Correa2012RolesON,
  title={Roles of NOD 1 ( NLRC 1 ) and NOD 2 ( NLRC 2 ) in innate immunity and inflammatory diseases},
  author={Ricardo G Correa and Snezana Milutinovic and John C. Reed},
  year={2012}
}
Synopsis NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat) family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the most prominent members of the NLR (NOD-LRR) family –proteins that contain nucleotide-binding NACHT domains and receptor-like LRR domains. With over 20 members identified in humans, NLRs represent important components of the mammalian innate immune system, serving as intracellular receptors for pathogens and for… CONTINUE READING

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