Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential.

  title={Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential.},
  author={Eetsin Wong and Vinay Tergaonkar},
  journal={Clinical science},
  volume={116 6},
The NF-kappaB (nuclear factor kappaB) family of transcription factors are involved in a myriad of activities, including the regulation of immune responses, maturation of immune cells, development of secondary lymphoid organs and osteoclastogenesis. Fine tuning by positive and negative regulators keeps the NF-kappaB signalling pathway in check. Microbial products and genetic alterations in NF-kappaB and other signalling pathway components can lead to deregulation of NF-kappaB signalling in… 

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