Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26. Implication for key amino acid residues for channel formation and function.

@article{Oshima2003RolesOM,
  title={Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26. Implication for key amino acid residues for channel formation and function.},
  author={Atsunori Oshima and Tomoko Doi and Kaoru Mitsuoka and Shoji Maeda and Yoshinori Fujiyoshi},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 3},
  pages={1807-16}
}
Connexins form a family of membrane proteins that assemble into communication channels and directly connect the cytoplasms of adjoining cells. Malfunctioning of connexin channels often cause disease, such as the mutations M34T and R75W in human connexin 26, which are associated with hereditary deafness. Another residue known to be essential for normal channel activity in the connexin is Cys-64. To obtain structural and functional insights of connexin 26, we studied the roles of these three… CONTINUE READING

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