Roles of LysP and CadC in mediating the lysine requirement for acid induction of the Escherichia coli cad operon.

@article{Neely1994RolesOL,
  title={Roles of LysP and CadC in mediating the lysine requirement for acid induction of the Escherichia coli cad operon.},
  author={Melody N. Neely and Cheryl L. Dell and Eric R. Olson},
  journal={Journal of bacteriology},
  year={1994},
  volume={176 11},
  pages={3278-85}
}
Expression of the Escherichia coli cadBA operon, encoding functions required for the conversion of lysine to cadaverine and for cadaverine excretion, requires at least two extracellular signals: low pH and a high concentration of lysine. To better understand the nature of the lysine-dependent signal, mutants were isolated which expressed a cadA-lacZ transcription fusion in the absence of lysine while retaining pH regulation. The responsible mutation in one of these isolates (EP310) was in cadC… CONTINUE READING