Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy.

@article{Eskelinen2006RolesOL,
  title={Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy.},
  author={Eeva-Liisa Eskelinen},
  journal={Molecular aspects of medicine},
  year={2006},
  volume={27 5-6},
  pages={495-502}
}
The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about 50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 or LAMP-2 are viable and fertile. However, mice deficient in both LAMP-1 and LAMP-2 have an embryonic lethal phenotype. These results show that these two major lysosomal membrane proteins share common functions in vivo. However, LAMP-2 seems to have more specific functions since LAMP-2 single deficiency has more severe… CONTINUE READING