Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.

@article{RomieuMourez2001RolesOI,
  title={Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.},
  author={Rapha{\"e}lle Romieu-Mourez and Esther Landesman-Bollag and David C. Seldin and Abdulmaged M Traish and Frank Mercurio and Gail E. Sonenshein},
  journal={Cancer research},
  year={2001},
  volume={61 9},
  pages={3810-8}
}
Nuclear factor-kappaB (NF-kappaB)/Rel transcription factors regulate genes that control cell proliferation, survival, and transformation. In normal breast epithelial cells, NF-kappaB/Rel proteins are mainly sequestered in the cytoplasm bound to one of the specific inhibitory IkappaB proteins, whereas in breast cancers they are activated aberrantly. Human breast tumor cell lines, carcinogen-transformed mammary epithelial cells, and the majority of primary human or rodent breast tumor tissue… CONTINUE READING

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