Roles of Glucose Transport and Glucose Phosphorylation in Muscle Insulin Resistance of NIDDM

@article{Bonadonna1996RolesOG,
  title={Roles of Glucose Transport and Glucose Phosphorylation in Muscle Insulin Resistance of NIDDM},
  author={Riccardo C Bonadonna and Enzo Bonora and Stefano del Prato and Maria Pia Saccomani and Claudio Cobelli and Andrea Natali and Silvia Frascerra and Neda Pecori and Ele Ferrannini and Dennis M. Bier and Ralph A. DeFronzo and Giovanni Gulli},
  journal={Diabetes},
  year={1996},
  volume={45},
  pages={915 - 925}
}
Insulin resistance for glucose metabolism in skeletal muscle is a key feature in NIDDM. The quantitative role of the cellular effectors of glucose metabolism in determining this insulin resistance is still imperfectly known. We assessed transmembrane glucose transport and intraceUular glucose phosphorylation in vivo in skeletal muscle in nonobese NIDDM patients. We performed euglycemic insulin clamp studies in combination with the forearm balance technique (brachial artery and deep forearm vein… Expand

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