Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.

@article{Zaibi2010RolesOG,
  title={Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.},
  author={Mohamed Zaibi and Claire J. Stocker and Jacqueline F. O'Dowd and Alison Davies and Mohamed Bellahcene and Michael Anthony Cawthorne and Alastair Brown and Davey M. Smith and Jonathan R. S. Arch},
  journal={FEBS letters},
  year={2010},
  volume={584 11},
  pages={2381-6}
}
GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)-stimulated leptin secretion by activating Galpha(i). Here, we agree with a contradictory report in finding no expression of GPR41 in murine adipose tissue. Nevertheless, in the presence of adenosine deaminase to minimise Galpha(i) signalling via the adenosine A1 receptor, SCFA stimulated leptin secretion by adipocytes from wild-type but not GPR41 knockout mice. Expression of GPR43 was reduced in… CONTINUE READING
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