Roles of G-protein-coupled receptor dimerization.

  title={Roles of G-protein-coupled receptor dimerization.},
  author={Sonia Terrillon and Michel Bouvier},
  journal={EMBO reports},
  volume={5 1},
The classical idea that G-protein-coupled receptors (GPCRs) function as monomeric entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings have indicated not only that many GPCRs exist as homodimers and heterodimers, but also that their oligomeric assembly could have important functional roles. Several studies have shown that dimerization occurs early after biosynthesis, suggesting that it has a primary role in receptor maturation. G-protein coupling, downstream… CONTINUE READING
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