Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.

Abstract

Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P2 to PtdIns-3,4,5-P3. This, in turn, recruits and activates cytosolic effectors with PtdIns-3,4,5-P3-binding pleckstrin homology (PH) domains, thereby controlling important cellular functions such as proliferation, survival, or… (More)

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@article{Brock2003RolesOG, title={Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.}, author={Carsten Brock and Michael Schaefer and Hans Peter Reusch and Cornelia Czupalla and Manuela Michalke and K. Spicher and Guenter Schultz and Bernd N{\"{u}rnberg}, journal={The Journal of cell biology}, year={2003}, volume={160 1}, pages={89-99} }