Roles of Estrogen Receptor-α Gene Expression in Reproduction-Related Behaviors in Female Mice* * This work was supported by the Harry Frank Guggenheim Foundation (to S.O.), the University of Missouri-Columbia molecular biology program (to D.B.L.), and NIH Grant HD-05751 (to D.W.P.).
The role of gene expression of the estrogen receptor-a form (ERa) in the regulation of female reproductive behavior was investigated in estrogen receptor knockout (ERKO) mice, deficient specifically for the ERa, but not the ERb, gene. Estrogenor estrogenplus progesteronetreated gonadectomized ERKO mice did not show any lordosis response. Detailed behavioral… (More)