Roles of DT diaphorase in the genotoxicity of nitroaromatic compounds in human and fish cell lines.

@article{Hasspieler1997RolesOD,
  title={Roles of DT diaphorase in the genotoxicity of nitroaromatic compounds in human and fish cell lines.},
  author={Bruce Hasspieler and G. Douglas Haffner and Khosrow Adeli},
  journal={Journal of toxicology and environmental health},
  year={1997},
  volume={52 2},
  pages={137-48}
}
The genotoxicity of nitroaromatic compounds was examined in two cultured cell lines, namely, a human hepatoma cell line, HepG2, and a brown bullhead fibroblast cell line, BB. Furthermore, the role of the quinone-reducing enzyme DT diaphorase [NAD(P)H:(quinone acceptor) oxidoreductase] was examined with respect to its influence on the genotoxic effects of model nitroaromatic pollutants. The nitroreductive characteristics of these two cell lines were examined using an acetylated cytochrome c… CONTINUE READING