Roles of DNA sequence and sigma A factor in transcription of the vraSR operon.

@article{Belcheva2012RolesOD,
  title={Roles of DNA sequence and sigma A factor in transcription of the vraSR operon.},
  author={Antoaneta Belcheva and Vidhu Verma and Artyom Korenevsky and Michael D. Fridman and K. Jayraj Kumar and Dasantila Golemi-Kotra},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 1},
  pages={61-71}
}
Cell wall damage in Staphylococcus aureus induces a rapid genome-wide response, referred to as the cell wall stress stimulon. This response is mediated by a two-component system, the vancomycin resistance-associated sensor/regulator (VraSR). The response regulator protein VraR is a transcription factor. Here, we demonstrate that two VraR binding sites in the vraSR operon control region are involved in the regulation of the vraSR operon. The sites are centered at the -60 and -35 nucleotide… CONTINUE READING

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