Roles of DNA helicases in the maintenance of genome integrity

@inproceedings{Bochman2014RolesOD,
  title={Roles of DNA helicases in the maintenance of genome integrity},
  author={Matthew L Bochman},
  booktitle={Molecular & cellular oncology},
  year={2014}
}
Genome integrity is achieved and maintained by the sum of all of the processes in the cell that ensure the faithful duplication and repair of DNA, as well as its genetic transmission from one cell division to the next. As central players in virtually all of the DNA transactions that occur in vivo, DNA helicases (molecular motors that unwind double-stranded DNA to produce single-stranded substrates) represent a crucial enzyme family that is necessary for genomic stability. Indeed, mutations in… CONTINUE READING