Roles of Chk1 in cell biology and cancer therapy.

@article{Zhang2014RolesOC,
  title={Roles of Chk1 in cell biology and cancer therapy.},
  author={Youwei Zhang and Tony Hunter},
  journal={International journal of cancer},
  year={2014},
  volume={134 5},
  pages={
          1013-23
        }
}
The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints preserve genome integrity. Central to these genome surveillance pathways is a protein kinase, Chk1. DNA damage induces activation of Chk1, which then transduces the checkpoint signal and facilitates cell cycle arrest and DNA damage repair. Significant progress has been made recently toward our understanding of Chk1 regulation and its implications in cancer etiology and therapy. Specifically, a model that involves… CONTINUE READING

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