Roles of Charged Residues in the Conserved Motif, G-X-X-X-D/E-R/K-X-G-[X]-R/K-R/K, of the Lactose Permease of Escherichia coli

Abstract

The lactose permease is a polytopic membrane protein that has a duplicated conserved motif, GXXX(D/E)(R/K)XG[X](R/K)(R/K), located in cytoplasmic loops 2/3 and 8/9. In the current study, the roles of the basic residues and the acidic residue were investigated in greater detail. Neutral substitutions of two positive charges in loop 2/3 were tolerated, while… (More)
DOI: 10.1007/s002320001029

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Cite this paper

@article{Pazdernik2000RolesOC, title={Roles of Charged Residues in the Conserved Motif, G-X-X-X-D/E-R/K-X-G-[X]-R/K-R/K, of the Lactose Permease of Escherichia coli}, author={Nanette Pazdernik and Elizabeth A M Matzke and A. E. Jessen-Marshall and Richard John Brooker}, journal={The Journal of Membrane Biology}, year={2000}, volume={174}, pages={31-40} }