Roles of Ca2+ influx and intracellular Ca2+ release in agonist-induced contractions in guinea pig trachea.

@article{Cuthbert1994RolesOC,
  title={Roles of Ca2+ influx and intracellular Ca2+ release in agonist-induced contractions in guinea pig trachea.},
  author={N J Cuthbert and Peggy Gardiner and Kevin Nash and Christopher T. Poll},
  journal={The American journal of physiology},
  year={1994},
  volume={266 6 Pt 1},
  pages={L620-7}
}
The contribution of receptor-operated Ca2+ channels (ROCs), voltage-operated Ca2+ channels (VOCs), and intracellular Ca2+ release to contractions induced by a range of stimuli in the guinea pig isolated trachea has been evaluated. In the presence of physiological Ca2+ (1.3 x 10(-3) M), tissue pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) (4 x 10(-3) M for 5 min) markedly inhibited (> 90%) the contractile responses to a range of agonists… CONTINUE READING

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