Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex

Abstract

Fragile X syndrome is caused by lack of fragile X mental retardation protein (FMRP) due to silencing of the FMR1 gene. The metabotropic glutamate receptors (mGluRs) in the central nervous system contribute to higher brain functions including learning/memory, mental disorders and persistent pain. The transcription factor cyclic AMP-responsive element binding… (More)
DOI: 10.1186/1756-6606-5-27

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